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br For overexpression purposes human
2020-08-12
For overexpression purposes, human APPBP2, PPM1D, and SPOP CDS were cloned into pCDNA 3·1, which was delivered into the cell lines by lipo-3000 (Invitrogen, L3000008). The expression of the genes was driven under CMV promoter. For BrdU in A549 (or H1299): 5 × 105 sh-NC infected cells and sh-APP
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br Conclusion BMS exhibits antitumor effects on
2020-08-12
Conclusion: BMS-777607 exhibits antitumor effects on ovarian cancer Tigecycline that constitutively express c-MET through c-MET signaling blockade and the inhibition of Aurora B activity. Combination treatments to enhance the effects of BMS-777607 warrant investigation in the future. © 2018 Taiwa
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br Cell proliferation was also evaluated by using EdU
2020-08-12
Cell proliferation was also evaluated by using EdU Kit (Millipore, USA). The proportion of EdU positive cells was determined by fluor-escence microscopy and FACS. Total cells were counted following nu-clear DAPI counterstaining. 2.5. Cell viability assay 2.6. Cell cycle analysis Cells wer
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br Fig Mutational signature associated
2020-08-12
Fig. 3. Mutational signature 3 associated with homologous recombination DNA repair defects in copy-number high (serous-like) endometrial cancers, high-grade serous ovarian cancers and basal-like breast cancers from The Cancer Genome Atlas. Mutational signatures were defined for copy-number high (s
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br Chinese Medical Association Production and hosting by
2020-08-12
© 2018 Chinese Medical Association. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Keywords: Cyclin E; Nuclear transcription factor Y subunit alp
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UAGACAUUGGGUUCGCCGUTT N A br siCul CCCUUGGAGAAAGACUUUAUA N A
2020-08-12
UAGACAUUGGGUUCGCCGUTT N/A siCul2 CCCUUGGAGAAAGACUUUAUA N/A siCul4B AAGGTGCGAGAAGATGTA N/A siCul3-1 AAGGUGCGAGAAGAUGUATT N/A siCul3-2 AACAACUUUCUUCAAACGCUA N/A siCul3-3 AACAACACUUGGCAAGGAGAC N/A siSPOP-1 CAACUAUCAUGCUUCGGAU N/A siSPOP-2 GGUAAAGGUUCCUGAGUGC N/A s
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br Morphological study br Untreated and treated cells with
2020-08-07
2.7. Morphological study Untreated and treated cells with 75 μg/mL of BHAE for 24 h were well washed with PBS (Gibco) then fixed for 30 min in the aqueous Bouin and colored with May Grunwald Giemsa (MGG) (Fluka; v/v). The observation was done and the using an inverted microscope (Zeiss). 2.8
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br essential for the generation
2020-08-07
essential for the generation of lamellipodial Belinostat (PXD101) networks [35]. As shown in Fig. 6B, the DLD-1 cells after Benp treatment changed to smaller and shrunken cells with a narrow band of F-actin at the cell periphery. In the cells stained for cortactin, lamellipodia were reduced
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br The Prevent macrosimulation model
2020-08-07
The Prevent macrosimulation model [8,9] was used to model projections of the number of cancer cases in the Nordic countries in the 30-year period, 2016e2045. A more detailed description of the Prevent model can be found elsewhere [9,10], and we used a similar approach as in other Nordic studies
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3X FLAG Peptide br Women were asked to
2020-08-06
Women were asked to click on the URL imbedded in the online study advertisement if they 3X FLAG Peptide wished to participate in the study. After reading the information statement and indicating their consent to participate, they were asked to list the cervical cancer screening bar-riers and facil
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br Table br Association of PARK
2020-08-06
Table 3 Association of PARK2 Promoter rs2276201, rs9347683 SNPs with clinicopathological, life style and environmental characteristics of colorectal cancer patients from North India. Characteristic rs2276201 Genotype(n) aOR P value Genotype(n) aOR P value (continued on next page)
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br After propensity score matching to balance factors that w
2020-08-06
After propensity score matching to balance factors that were associated with the receipt of MRI, standardized differences for all variables were less than 10% between patients who received prostate MRI and their matched counterparts, indicating ade-quate matching based on the selected characterist
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br Gastrointestinal symptoms Group A Group B
2020-08-05
Gastrointestinal symptoms Group A Group B Group C p p p Legend: Me – median value; Min – minimum; max – maximum; p Table 7 Comparison of frequency domain HRV parameters in patients groups with cancer and healthy controls. Parameter Group A Group B Group C Controls p p p p
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br Introduction br Lung cancer is a very common
2020-08-04
1. Introduction Lung cancer is a very common cancer and the leading cause of cancer-related deaths worldwide [1,2]. Despite recent advances in clinical practice, including target therapies, however, the 5-year sur-vival rate of lung cancer remains at approximately 16%. One of the main reasons b
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br Results br ART inhibits proliferation of T cells
2020-08-04
3. Results 3.1. ART inhibits proliferation of 4T1 cells ART has been shown to considerably inhibit the proliferation of certain breast cancer cells, but this effect has not been demonstrated in 4T1 cells. Therefore, we performed an MTT assay to examine 4T1 cell proliferation after ART treatme